The amazing and ancient Farmacia Santa Maria della Scala in Rome is literally a hidden gem tucked away in the popular Trastevere neighborhood. It has been operating since the 16th century, making use of natural remedies to heal an array of illnesses, including chest infections, allergies, and even rheumatic disorders. Over time, the friars managing it rose to such an expertise in botany, chemistry, and medicine, that they were appointed as the “pharmacy of the Popes”. Since the end of the 17th century, it has welcomed ordinary people, as well as noble families, becoming Europe's oldest pharmacy. Although its entrance door is easy to miss, this is definitely a place to visit when in Rome and discover its fascinating history.