Montepulciano is a medieval and Renaissance hill town and comune in the Italian province of Siena in southern Tuscany. It sits high on a 605-metre (1,985 ft) limestone ridge, 13 kilometres (8 mi) east of Pienza, 70 kilometres (43 mi) southeast of Siena, 124 kilometres (77 mi) southeast of Florence, and 186 kilometres (116 mi) north of Rome by car.

Montepulciano is a wine-producing region. The Vino Nobile di Montepulciano has Denominazione di origine controllata e garantita status and is, with the Brunello di Montalcino and Chianti Classico, one of the principal red wines of Tuscany. The Rosso di Montepulciano and Vin Santo di Montepulciano have Denominazione di origine controllata status.